Publications
Prof. Dr. Schambony
2020
Dietrich P. , Wormser L. , Fritz V. , Seitz T. , de Maria M. , Schambony A. , Kremer A. , Günther C. , Itzel T. , Thasler WE. , Teufel A. , Trebicka J. , Hartmann A. , Neurath M. , von Hörsten S. , Boßerhoff AK. , Hellerbrand C. :Molecular cross-talk between Y5-receptor and neuropeptide Y drives liver cancer In: Journal of Clinical Investigation 130 (2020 ), p. 2509-2526 ISSN: 0021-9738 DOI: 10.1172/JCI131919
Ebersberger L. , Schindler T. , Kirsch S. , Pluhackova K. , Schambony A. , Seydel T. , Böckmann R. , Unruh T. :Lipid Dynamics in Membranes Slowed Down by Transmembrane Proteins In: Frontiers in Cell and Developmental Biology 8 (2020 )ISSN: 2296-634X DOI: 10.3389/fcell.2020.579388
Küppers M. , Kashkanova A. , Lühr J. , Albrecht D. , Schambony A. , Sandoghdar V. :Label-free live-cell imaging with interferometric scattering microscopy: Confocal imaging and high-speed 3D single particle tracking Microscopy Histopathology and Analytics, Microscopy 2020 (Washington, DC , April 20, 2020 - April 23, 2020 )In: Optics InfoBase Conference Papers 2020 DOI: 10.1364/MICROSCOPY.2020.MW1A.4
Taylor RW. , Holler C. , Mahmoodabadi RG. , Küppers M. , Mirzaalian Dastjerdi H. , Zaburdaev V. , Schambony A. , Sandoghdar V. :High-Precision Protein-Tracking With Interferometric Scattering Microscopy In: Frontiers in Cell and Developmental Biology 8 (2020 ), Article No.: 590158 ISSN: 2296-634X DOI: 10.3389/fcell.2020.590158
2019
Harnos J. , Canizal MCA. , Jurasek M. , Kumar J. , Holler C. , Schambony A. , Hanakova K. , Bernatik O. , Zdrahal Z. , Gomoryova K. , Gybel T. , Radaszkiewicz TW. , Kravec M. , Trantirek L. , Rynes J. , Dave Z. , Fernandez-Llamazares AI. , Vacha R. , Tripsianes K. , Hoffmann C. , Bryja V. :Dishevelled-3 conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1 In: Nature Communications 10 (2019 ), Article No.: 1804 ISSN: 2041-1723 DOI: 10.1038/s41467-019-09651-7
Taylor R. , Mahmoodabadi RG. , Schambony A. , Sandoghdar V. :High-resolution, three-dimensional investigation of protein diffusion and trafficking in the live HeLa cell via interferometrie scattering microscopy (iSCAT) 2019 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference, CLEO/Europe-EQEC 2019 (Munich , June 23, 2019 - June 27, 2019 )In: 2019 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference, CLEO/Europe-EQEC 2019 2019 DOI: 10.1109/CLEOE-EQEC.2019.8872206
Taylor RW. , Mahmoodabadi RG. , Rauschenberger V. , Gießl A. , Schambony A. , Sandoghdar V. :Interferometric scattering microscopy reveals microsecond nanoscopic protein motion on a live cell membrane In: Nature Photonics (2019 )ISSN: 1749-4885 DOI: 10.1038/s41566-019-0414-6
2018
Bernkopf D. , Jalal K. , Brückner M. , Knaup KX. , Gentzel M. , Schambony A. , Behrens J. :Pgam5 released from damaged mitochondria induces mitochondrial biogenesis via Wnt signaling In: The Journal of Cell Biology 217 (2018 ), p. 1383-1394 ISSN: 0021-9525 DOI: 10.1083/jcb.201708191
Mielenz D. , Reichel M. , Jia T. , Quinlan EB. , Stöckl T. , Mettang M. , Zilske D. , kirmizi Alsan E. , Schoenberger P. , Praetner M. , Huber S. , Amato D. , Schwarz M. , Purohit P. , Brachs S. , Spranger J. , Heß A. , Büttner C. , Ekici AB. , Perez-Branguli F. , Winner B. , Rauschenberger V. , Banaschewski T. , Bokde ALW. , Buechel C. , Conrod PJ. , Desrivieres S. , Flor H. , Frouin V. , Gallinat J. , Garavan H. , Gowland P. , Heinz A. , Martinot JL. , Lemaitre H. , Nees F. , Paus T. , Smolka MN. , Schambony A. , Bäuerle T. , Eulenburg V. , Alzheimer C. , Lourdusamy A. , Schumann G. , Müller CP. :EFhd2/Swiprosin-1 is a common genetic determinator for sensation-seeking/low anxiety and alcohol addiction In: Molecular Psychiatry 23 (2018 ), p. 1303-1319 ISSN: 1359-4184 DOI: 10.1038/mp.2017.63
Müller CP. , Reichel M. , Jia T. , Quinlan EB. , Schambony A. , Bäuerle T. , Eulenburg V. , Lourdusamy A. , Schumann G. , Mielenz D. :EFHD2/SWIPROSIN-1 IS A CONSERVED RESILIENCE FACTOR AGAINST ALCOHOL DRINKING ESCALATION
2017
Gentzel M. , Schambony A. :Dishevelled Paralogs in Vertebrate Development: Redundant or Distinct? In: Frontiers in Cell and Developmental Biology 5 (2017 ), p. 59 ISSN: 2296-634X DOI: 10.3389/fcell.2017.00059
Mielenz D. , Jia T. , Quinlan EB. , Stöckl T. , Mettang M. , Zilske D. , kirmizi Alsan E. , Schönberger P. , Praetner M. , Huber SE. , Amato D. , Schwarz M. , Purohit P. , Brachs S. , Spranger J. , Heß A. , Büttner C. , Ekici AB. , Perez-Branguli F. , Winner B. , Rauschenberger V. , Banaschewski T. , Bokde A. , Büchel C. , Conrod P. , Desrivieres S. , Flor H. , Frouin V. , Gallinat J. , Garavan H. , Gowland P. , Heinz A. , Martinot JL. , Lemaitre H. , Nees F. , Paus T. , Smolka M. , Schambony A. , Bäuerle T. , Eulenburg V. , Alzheimer C. , Lourdusamy A. , Schumann G. , Müller CP. :EFhd2/Swiprosin-1 is a common genetic determinator for sensation-seeking/low anxiety and alcohol addiction In: Molecular Psychiatry (2017 )ISSN: 1476-5578 DOI: 10.1038/mp.2017.63
Rauschenberger V. , Bernkopf D. , Krenn S. , Jalal K. , Heller J. , Behrens J. , Gentzel M. , Schambony A. :The phosphatase Pgam5 antagonizes Wnt/β-catenin signaling in embryonic anterior-posterior axis patterning In: Development 144 (2017 ), p. 2234-2247 ISSN: 1477-9129 DOI: 10.1242/dev.144477
Schille C. , Schambony A. :Signaling pathways and tissue interactions in neural plate border formation In: Neurogenesis 4 (2017 ), p. e1292783 ISSN: 2326-2133 DOI: 10.1080/23262133.2017.1292783 URL: https://www.tandfonline.com/doi/full/10.1080/23262133.2017.1292783
Stricker S. , Rauschenberger V. , Schambony A. :ROR-Family Receptor Tyrosine Kinases. In: Current Topics in Developmental Biology 123 (2017 ), p. 105-142 ISSN: 0070-2153 DOI: 10.1016/bs.ctdb.2016.09.003 URL: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28236965&retmode=ref&cmd=prlinks
2016
Bleckmann A. , Conradi LC. , Menck K. , Schmick NA. , Schubert A. , Rietkoetter E. , Arackal J. , Middel P. , Schambony A. , Liersch T. , Homayounfar K. , Beissbarth T. , Klemm F. , Binder C. , Pukrop T. :β-catenin-independent WNT signaling and Ki67 in contrast to the estrogen receptor status are prognostic and associated with poor prognosis in breast cancer liver metastases. In: Clinical & Experimental Metastasis 33 (2016 ), p. 309-323 ISSN: 0262-0898 DOI: 10.1007/s10585-016-9780-3 URL: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26862065&retmode=ref&cmd=prlinks
Chen C-. , Lin N-. , Zhang Y. , Huang J. , Palumbo-Zerr K. , Schambony A. , Beyer C. , Schett G. , Distler J. :WNT5A PROMOTES FIBROBLAST ACTIVATION AND TISSUE FIBROSIS BY ROR2/RYK DEPENDENT ACTIVATION OF PCP-SIGNALING
Larisch N. , Kirsch S. , Schambony A. , Studtrucker T. , Böckmann R. , Dietrich P. :The function of the two-pore channel TPC1 depends on dimerization of its carboxy-terminal helix. In: Cellular and Molecular Life Sciences 73 (2016 ), p. 2565-81 ISSN: 1420-682X DOI: 10.1007/s00018-016-2131-3
Schille C. , Bayerlova M. , Bleckmann A. , Schambony A. :Ror2 signaling is required for local upregulation of GFD6 and activation of BMP signaling at the neural plate border In: Development 143 (2016 ), p. 3182-3194 ISSN: 1477-9129 DOI: 10.1242/dev.135426
Schille C. , Heller J. , Schambony A. :Differential requirement of bone morphogenetic protein receptors Ia (ALK3) and Ib (ALK6) in early embryonic patterning and neural crest development. In: Bmc Developmental Biology 16 (2016 ), p. 1 ISSN: 1471-213X DOI: 10.1186/s12861-016-0101-5 URL: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26780949&retmode=ref&cmd=prlinks
2015
2014
Bernatik O. , Sedova K. , Schille C. , Ganji RS. , Cervenka I. , Trantirek L. , Schambony A. , Zdrahal Z. , Bryja V. :Functional analysis of dishevelled-3 phosphorylation identifies distinct mechanisms driven by casein kinase 1ϵ and frizzled5. In: Journal of Biological Chemistry 289 (2014 ), p. 23520-23533 ISSN: 0021-9258 DOI: 10.1074/jbc.M114.590638 URL: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24993822&retmode=ref&cmd=prlinks
Schambony A. , Zaman GJ. , Verkaar F. :Molecular Mechanisms of Wnt Pathway Specificity In: Hoppler SP, Moon RT (ed.): Wnt Signaling in Development and Disease , John Wiley & Sons , 2014 , p. 101-112 ISBN: 1118444094 DOI: 10.1002/9781118444122.ch7
Seitz K. , Duersch V. , Harnos J. , Bryja V. , Gentzel M. , Schambony A. :β-Arrestin interacts with the beta/gamma subunits of trimeric G-proteins and dishevelled in the Wnt/Ca(2+) pathway in xenopus gastrulation. In: PLoS ONE 9 (2014 ), Article No.: e87132 ISSN: 1932-6203 DOI: 10.1371/journal.pone.0087132 URL: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24489854&retmode=ref&cmd=prlinks
2013
2012
Pfister A. , Hadjihannas M. , Roehrig W. , Schambony A. , Behrens J. :Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration. In: Journal of Biological Chemistry 287 (2012 ), p. 35333-35340 ISSN: 0021-9258 DOI: 10.1074/jbc.M112.385393 URL: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22898821&retmode=ref&cmd=prlinks
Pfister A. , Tanneberger K. , Schambony A. , Behrens J. :Amer2 protein is a novel negative regulator of Wnt/β-catenin signaling involved in neuroectodermal patterning. In: Journal of Biological Chemistry 287 (2012 ), p. 1734-1741 ISSN: 0021-9258 DOI: 10.1074/jbc.M111.308650 URL: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22128170&retmode=ref&cmd=prlinks
Schulte G. , Bryja V. , Schambony A. :19th Acta Physiologica international symposium ‘WNT Signaling in Physiology and Disease’– a long way from developmental biology to physiology In: Acta Physiologica 204 (2012 ), p. 6-7 ISSN: 1748-1708 DOI: 10.1111/j.1748-1716.2011.02326.x URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1748-1716.2011.02326.x/full
Tauriello DVF. , Jordens I. , Kirchner K. , Slootstra JW. , Kruitwagen T. , Bouwman BAM. , Noutsou M. , Rudiger SGD. , Schwamborn K. , Schambony A. , Maurice MM. :Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled. In: Proceedings of the National Academy of Sciences of the United States of America 109 (2012 ), p. E812-20 ISSN: 0027-8424 DOI: 10.1073/pnas.1114802109 URL: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22411803&retmode=ref&cmd=prlinks
2011
Jung B. , Koehler A. , Schambony A. , Wedlich D. :PAPC and the Wnt5a/Ror2 pathway control the invagination of the otic placode in Xenopus. In: Bmc Developmental Biology 11 (2011 ), p. 36 ISSN: 1471-213X DOI: 10.1186/1471-213X-11-36 URL: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21663658&retmode=ref&cmd=prlinks
Kagermeier-Schenk B. , Wehner D. , Oezhan-Kizil G. , Yamamoto H. , Li J. , Kirchner K. , Hoffmann C. , Stern P. , Kikuchi A. , Schambony A. , Weidinger G. :Waif1/5T4 inhibits Wnt/β-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization. In: Developmental Cell 21 (2011 ), p. 1129-1143 ISSN: 1534-5807 DOI: 10.1016/j.devcel.2011.10.015 URL: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22100263&retmode=ref&cmd=prlinks
Tanneberger K. , Pfister A. , Kriz V. , Bryja V. , Schambony A. , Behrens J. :Structural and functional characterization of the Wnt inhibitor APC membrane recruitment 1 (Amer1). In: Journal of Biological Chemistry 286 (2011 ), p. 19204-19214 ISSN: 0021-9258 DOI: 10.1074/jbc.M111.224881 URL: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21498506&retmode=ref&cmd=prlinks
2010
Feike AC. , Rachor K. , Gentzel M. , Schambony A. :Wnt5a/Ror2-induced upregulation of xPAPC requires xShcA. In: Biochemical and Biophysical Research Communications 400 (2010 ), p. 500-506 ISSN: 0006-291X DOI: 10.1016/j.bbrc.2010.08.074 URL: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20732301&retmode=ref&cmd=prlinks
Schneider M. , Schambony A. , Wedlich D. :Prohibitin1 acts as a neural crest specifier in Xenopus development by repressing the transcription factor E2F1 In: Development 137 (2010 ), p. 4073-4081 ISSN: 1477-9129 DOI: 10.1242/dev.053405
Schulte G. , Schambony A. , Bryja V. :β-arrestins - Scaffolds and signalling elements essential for WNT/Frizzled signalling pathways? In: British Journal of Pharmacology 159 (2010 ), p. 1051-1058 ISSN: 0007-1188 DOI: 10.1111/j.1476-5381.2009.00466.x
Witte F. , Bernatik O. , Kirchner K. , Masek J. , Mahl A. , Krejci P. , Mundlos S. , Schambony A. , Bryja V. , Stricker S. :Negative regulation of Wnt signaling mediated by CK1-phosphorylated Dishevelled via Ror2. In: The FASEB Journal 24 (2010 ), p. 2417-2426 ISSN: 0892-6638 DOI: 10.1096/fj.09-150615 URL: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20215527&retmode=ref&cmd=prlinks
2009
Bryja V. , Andersson ER. , Schambony A. , Esner M. , Bryjova L. , Biris KK. , Hall AC. , Kraft B. , Cajanek L. , Yamaguchi TP. , Buckingham M. , Arenas E. :The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo. In: Molecular Biology of the Cell 20 (2009 ), p. 924-936 ISSN: 1059-1524 DOI: 10.1091/mbc.E08-07-0711 URL: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=19056682&retmode=ref&cmd=prlinks
Van Wijk NV. , Witte F. , Feike AC. , Schambony A. , Birchmeier W. , Mundlos S. , Stricker S. :The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling. In: Biochemical and Biophysical Research Communications 390 (2009 ), p. 211-216 ISSN: 0006-291X DOI: 10.1016/j.bbrc.2009.09.086 URL: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=19785987&retmode=ref&cmd=prlinks
2008
Kalinina S. , Gliemann H. , Lopez-Garcia M. , Petershans A. , Auernheimer J. , Schimmel T. , Bruns M. , Schambony A. , Kessler H. , Wedlich D. :Isothiocyanate-functionalized RGD peptides for tailoring cell-adhesive surface patterns. In: Biomaterials 29 (2008 ), p. 3004-3013 ISSN: 0142-9612 DOI: 10.1016/j.biomaterials.2008.04.003 URL: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=18433862&retmode=ref&cmd=prlinks
2007
2004
2003
Liao Q, Kleeff J, Xiao Y, Guweidhi A, Schambony A, Töpfer-Petersen E, Zimmermann A, Büchler MW, Friess H:Preferential expression of cystein-rich secretory protein-3 (CRISP-3) in chronic pancreatitis. In: Histology and Histopathology 18 (2003 ), p. 425-433 ISSN: 0213-3911 DOI: 10.14670/HH-18.425 URL: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=12647793&retmode=ref&cmd=prlinks
Schambony A. , Hefele J. , Gentzel M. , Wilm M. , Wedlich D. :A homologue of cysteine-rich secretory proteins induces premature degradation of vitelline envelopes and hatching of Xenopus laevis embryos. In: Mechanisms of Development 120 (2003 ), p. 937-948 ISSN: 0925-4773 DOI: 10.1016/S0925-4773(03)00162-X URL: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=12963113&retmode=ref&cmd=prlinks
Schambony A. , Wedlich D. :Wnt Signaling and Cell Migration In: Michael Kühl (ed.): Wnt Signaling in Development , Springer Science & Business Media , 2003 , p. 240-250 ISBN: 0306478382, 9780306478383
2002
1998
Schambony A, Gentzel M, Wolfes H, Raida M, Neumann U, Töpfer-Petersen E:Equine CRISP-3: primary structure and expression in the male genital tract. In: Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 1387 (1998 ), p. 206-216 ISSN: 0167-4838 DOI: 10.1016/S0167-4838(98)00122-8 URL: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=9748582&retmode=ref&cmd=prlinks
Schambony A, Hess O, Gentzel M, Töpfer-Petersen E:Expression of CRISP proteins in the male equine genital tract. In: Journal of reproduction and fertility. Supplement 53 (1998 ), p. 67-72 ISSN: 0449-3087 URL: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=10645267&retmode=ref&cmd=prlinks
Töpfer-Petersen E, Waberski D, Hess O, Bellair S, Schambony A, EKHLASI-HUNDRIESER M, Gentzel M, REINEKE A:The role of seminal plasma in fertilisation In: Tieraerztliche Umschau 53 (1998 ), p. 447-454 ISSN: 0049-3864 URL: http://espace.library.uq.edu.au/view/UQ:280792
1997